Tuberculosis allergen

Tuberculin Purified Protein Derivative


Trade name: Purified tuberculosis allergen in standard dilution (purified tuberculin in standard dilution).

Dosage form: solution for intradermal injection.

Tuberculin Purified Protein Derivative is the filtrate containing the mixture of heat-killed germ culture of human and bovine tuberculosis, which is purified by ultrafiltration, precipitated by trichloracetic acid, treated with ethyl alcohol and ether for anesthesia, and dissolved in a stabilizing solvent.

Description. Colorless transparent liquid.

Pharmacotherapeutic group. MIBD - allergen.

ATC code. V04CF01.

Biological and immunological properties. The active ingredient, allergen tuberculoprotein, causes a specific delayed hypersensitivity reaction in the form of local reaction, hyperemia and infiltrate (papula), after making an intracutaneous tuberculin test in the infected or vaccinated people.

Indications for use. The drug is intended for large-scale tuberculinodiagnosis:

а)  selection of persons for BCG booster vaccination and before the initial vaccination in children at the age of 2 months or older;

b)  tuberculosis diagnostics, also for the purpose of early detection of initial and local tuberculosis in children and adolescents;

c)  determination of contamination with tuberculosis bacteria.


- generalized skin diseases;

- acute, chronic infectious and somatic diseases during the exacerbation period;

- allergic conditions (bronchial asthma, idiosyncrasies with severe skin manifestations in the exacerbation period);

- rheumatism in the acute and subacute phases;

- epilepsy.

A Mantoux test is made 1 month after the disappearance of all clinical symptoms or immediately after cessation of the quarantine in the children facility. A Mantoux test is not allowed in children groups that are under quarantine for children infections. 

In order to identify contraindications, a doctor (nurse) should conduct a survey and examination of persons to be tested on the day of tuberculin diagnosis.

Precautions for use. Preventive vaccination can impact the sensitivity to tuberculin. Preventive vaccines can affect sensitivity to tuberculin. Therefore, tuberculin diagnostics should be scheduled before preventive vaccinations against various infections. If a preventive vaccination has been carried out, tuberculin diagnostics should be carried out no earlier than 1 month after the vaccination.

The product contains less than 1 mmol (39 mg) of potassium and less than 1 mmol (23 mg) of sodium per dose (0.1 ml) i.e. it practically does not contain potassium and sodium.

Medical devices